The purpose of this study is to examine the effects of bile acids on GLP-1 secretion after Roux-en-Y gastric bypass.
Study Type
INTERVENTIONAL
Allocation
NON_RANDOMIZED
Purpose
BASIC_SCIENCE
Masking
NONE
Enrollment
11
Hvidovre University Hospital
Hvidovre, Denmark
GLP-1 secretion (evaluated by iAUC)
Time frame: Baseline, 0, 5, 10, 15, 20, 25, 30, 45, 60, 90, 120, 180
C-peptide secretion (evaluated by iAUC)
Time frame: Baseline, 0, 5, 10, 15, 20, 25, 30, 45, 60, 90, 120, 180
PYY secretion (evaluated by iAUC)
Time frame: Baseline, 0, 5, 10, 15, 20, 25, 30, 45, 60, 90, 120, 180
Glucagon secretion (evaluated by iAUC)
Time frame: Baseline, 0, 5, 10, 15, 20, 25, 30, 45, 60, 90, 120, 180
GIP secretion (evaluated by iAUC)
Time frame: Baseline, 0, 5, 10, 15, 20, 25, 30, 45, 60, 90, 120, 180
CCK secretion (evaluated by iAUC)
Time frame: Baseline, 0, 5, 10, 15, 20, 25, 30, 45, 60, 90, 120, 180
Gherlin secretion (evaluated by iAUC)
Time frame: Baseline, 0, 5, 10, 15, 20, 25, 30, 45, 60, 90, 120, 180
Changes in bile acids/FGF-19
Time frame: Baseline, 0, 5, 10, 15, 20, 25, 30, 45, 60, 90, 120, 180
TSH/T3/T4
Time frame: 0, 60, 120, 180
Appetite measurements (VAS-score)
Time frame: Baseline, 30, 60, 120, 180
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