The Impact of the Glycaemic Index (GI) on Daily Blood Glucose Profiles and Food Intake in Young Chinese Adult Males

Singapore Institute of Food and Biotechnology Innovation15 enrolled

Overview

This study is carried out to find out the inclusion of high and low glycaemic Index (GI) foods to daily meals impact on 24 hour blood glucose fluctuations and food intake.

The GI is a method of classifying foods based on the food's ability to raise the blood glucose level. Low GI foods are recommended as they have a lower impact on blood glucose concentrations and also reduce total food intake. There is very little information on how eating high and low GI foods affect daily blood glucose concentrations in Asians. Therefore, the objective of this study is to observe the effect of eating high and low GI breakfasts and snacks on 24 hour blood glucose concentrations and food consumption in Asian males. Healthy, normal-weight, Chinese males will be recruited. There will be two sessions (consisting of four days for each session) where they will consume either a high or low GI breakfast or snack, and a standardized ad libitum lunch buffet. Their glycaemic response will be measured using a Continuous Glucose Monitoring System (CGMS) throughout the period. The proposed research for the first time demonstrates how the consumption of high and low GI breakfasts and snacks affect subsequent energy intake and 24 hour blood glucose profiles in Asians. These findings will have significant public health benefits for optimum weight and dietary control.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Masking

NONE

Enrollment

Conditions

Type 2 Diabetes Obesity Prediabetes

Interventions

Rice and bread (high GI)OTHER

Rice is a high glycaemic index glutinous rice. Bread is a high glycaemic index white bread.

Rice and bread (low GI)OTHER

Rice is a low glycaemic index parboiled basmati rice. Bread is a low glycaemic index multigrain bread.

Eligibility

Sex: MALEMin age: 21 YearsMax age: 40 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * Chinese, male * Age between 21-40 years * Body mass index between 17 to 24 kg/m2 * Normal blood pressure (120/80 Hgmm) * Fasting blood glucose \< 6 mmol/L Exclusion Criteria: * Having any metabolic diseases (such as diabetes, hypertension etc) * One prescription medication * Partaking in sports at the competitive and/or endurance levels * Allergic/intolerant to any of the test foods * Intentionally restricting food intake * Smoking

Outcomes

Primary Outcomes

Glycaemic response (measured 3 hours post consumption using the Continuous Glucose Monitoring System (CGMS)

The blood glucose response to low and high GI test foods measured 3 hours post consumption using the Continuous Glucose Monitoring System (CGMS)

Time frame: 3 hours post consumption

Daily blood glucose profile (easured for each low and high GI treatment as the area under the curve over 24 hours using CGMS)

The daily total blood glucose response is measured for each low and high GI treatment as the area under the curve over 24 hours using CGMS.

Time frame: 24 hours

Secondary Outcomes

Energy intake (The amount of food consumed at the ad libitum lunch is measured by weighed quantities (in grams converted to kilocalories) based on the difference of the weight of food before and after consumption)

The amount of food consumed at the ad libitum lunch is measured by weighed quantities (in grams converted to kilocalories) based on the difference of the weight of food before and after consumption

Time frame: Immediately post meal consumption

Data from ClinicalTrials.gov

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