Endothelial Dysfunction Evaluation for Coronary Heart Disease Risk Estimation in Rheumatoid Arthritis (EDRA Study)

Inclusion Criteria: * RA as defined by American College of Rheumatology/European League Against Rheumatisms 2010 RA classification criteria * In the opinion of investigators, patients must be able to adhere to the study visit schedule and must be capable of giving informed consent Exclusion Criteria: * Previous cardiovascular or cerebrovascular events (acute coronary syndrome, stable angina, stroke, interventional procedures, carotid endarterectomy, symptomatic peripheral artery ischemia) * Pathological ECG at rest * Sign or symptoms of autonomous nervous system dysfunction * Serious infections in the previous 6 months * Concomitant severe illness: overt hepatic insufficiency; End stage renal disease (Glomerular Filtration Rate \<30 ml/h at Cockrofts-Gault formula); recent diagnosis of cancer * Pregnancy * Plans to leave target areas of each study site within three years