Three Measures for the Prevention of Carious Lesions in Preschool Children

Zhejiang University500 enrolled

Overview

Analysis different measures preventive effect on carious Lesions incidence and oral microecological system change of preschool children

Different caries prevention trials including fluoride vanish, IgY-passive immunotherapy and probiotics lasting 24 months were conducted with a total of 500 children aged 24 to 54 months of age in Lin'an, Zhejiang, China. The trials were cluster- domized .After obtaining parent´s informed consent, preschool children were clinical examinated according to ICDAS-Ⅱ and microbiological tested of saliva at baseline, 1m, 6m, 12m, 18m and 24m. To find the differences of caries incidence and oral microecology change in four groups, dmfs will be assessed and saliva will be analysed in experiment.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

HEALTH_SERVICES_RESEARCH

Masking

DOUBLE

Enrollment

500

Conditions

Dental Caries

Interventions

fluoride varnishDRUG

Sodium fluoride 50mg/ml

Immunoglobulin YolkBIOLOGICAL

anti-Streptococcus mutans IgY

ProbioticsDIETARY_SUPPLEMENT

2g/day，Lactobacillus rhamnosus HN001, Bifidobacterium lactis Bi-07, Bifidobacterium lactis HN019, maltodextrin, fructose, skimmed milk powder

Eligibility

Sex: ALLMin age: 24 MonthsMax age: 54 MonthsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * preschool children in good general health * At least 18 deciduous teeth Exclusion Criteria: * With major systemic disease or on long-term medication * Not cooperative and refuse dental treatment * With a history of extra fluoride supplement * Take antibiotics for nearly 8 weeks

Locations (1)

Affiliated Hospital of Stomatology, School of Medicine, Zhejiang University

Hangzhou, Zhejiang, China

Outcomes

Primary Outcomes

The number of new cavitated or incipient carious lesion

To determine whether preschool children that only with caregiver behavior education have more new caries lesion than those taken some caries preventive measures by differences in dmfs（decay，missing，filling teeth surfaces） index after 24 months dental exams.

Time frame: 24 months after first visit

Data from ClinicalTrials.gov

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