Vitamin D Influence on Oocyte Donation

IVI Madrid269 enrolled

Overview

Objective: To investigate the correlation between total and bioavailable serum 25-OH vitamin D, ovarian reserve and ovarian response to controlled stimulation in egg donors.

Design: Retrospective study. Setting: University affiliated private IVF center. Intervention: Serum analysis of vitamin D, bioavailable vitamin D, antimullerian hormone (AMH), antral follicular count (AFC), reproductive outcome of oocytes recipients Main outcome measure: AMH, AFC, number of oocytes retrieved and number of mature oocytes, pregnancy and implantation rate of donated oocytes'recipients.

Study Type

OBSERVATIONAL

Enrollment

269

Conditions

Disorder of Phosphate, Calcium and Vitamin D Metabolism Female Infertility Due to Diminished Ovarian Reserve Hormonal Requirement Reproductive Disorder

Interventions

vitamin D,AMH, AFC, reproductive outcome egg recipientsOTHER

observational study of 269 donnors

Eligibility

Sex: FEMALEMin age: 18 YearsMax age: 34 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Caucasian race, * between 18 and 34 years of age, * all donors had normal menstrual cycles of 26-34 days, * normal weight range (BMI 18- 25 Kg/m2), * normal uterus and ovaries on transvaginal ultrasound (no signs of polycystic ovarian syndrome), and * an antral follicle count (AFC) \>10, * normal karyotype Exclusion Criteria: * current or past exposure to radiation or hazardous chemical substances, * history of drug use, * family history of hereditary chromosomal diseases, * sexually transmitted diseases

Outcomes

Primary Outcomes

Numbers of oocytes retrieved

Time frame: 2 months

Secondary Outcomes

implantation rate

Time frame: 2 months

pregnancy rate

Time frame: 2 months

AFC

Time frame: 2 months

number of mature oocytes

Time frame: 2 months

AMH

Time frame: 2 months

Data from ClinicalTrials.gov

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