Postoperative Cognitive Disorders (POCD) are common in hospitalized people \> 60 year old, especially in orthopedic patients. Etiology of POCD is complex, and in some aspects still remains unclear. The role of thromboembolic events in etiology of POCD was discussed. The incidence of such events in patients who underwent big joints arthroplasty can be as high as 40 to 60%, although some cases are subclinical. Thromboembolic material can block a blood flow through a vessels in the brain. As a consequence cerebral neurons can be damaged or destroyed. After neuronal damage specific substances, such as S100B protein, glial fibrillary acidic protein (GFAP) and neuron-specific enolase (NSE) are released to the blood. The serum concentrations of these biomarkers can be measured. Moreover, the block of blood flow will decrease regional cerebral saturation in affected parts of the brain. In this project the authors would like to analyze the correlation between the regional cerebral saturation and serum concentration of both S100B protein and GFAP in orthopedic patients scheduled to primary hip arthroplasty.
Study Type
INTERVENTIONAL
Allocation
NON_RANDOMIZED
Purpose
DIAGNOSTIC
Masking
SINGLE
Enrollment
18
Department of Anesthesiology and Intensive Therapy
Warsaw, Poland
Changes in regional cerebral oxygen during primary hip arthroplasty
The analysis of regional cerebral oxygen saturation will start just before the anesthesia and ends just after the surgery.
Time frame: Duration of the orthopedic procedure, an expected average of 2 hours.
Changes in serum levels of S100B protein from baseline at 72 hours after the surgery
The serum concentration of S100B protein will be measured \[1\] just before the surgery, \[2\] just after the end of the surgery, an expected average of two hours, \[3\] 6 hours after the beginning of the surgery, \[4\] 24 hours after the beginning of the surgery, and \[5\] 72 hours after the beginning of the surgery.
Time frame: 72 hours
Changes in serum levels of GFAP from baseline at 72 hours after the surgery
The serum concentration of GFAP protein will be measured \[1\] just before the surgery, \[2\] just after the end of the surgery, an expected average of two hours, \[3\] 6 hours after the beginning of the surgery, \[4\] 24 hours after the beginning of the surgery, and \[5\] 72 hours after the beginning of the surgery.
Time frame: 72 hours
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