Probiotics Against Low Grade Inflammation and Increased Intestinal Permeability in the Elderly

Probi AB66 enrolled

Overview

The purpose of this study is to evaluate the ability of a blend of berries and probiotics in reducing low-grade inflammation and intestinal permeability in the elderly. The intervention period is one month. Blood and fecal samples will be collected for analysis at baseline and at the end of the intervention with the aim to analyse possible changes in different parameters at the two timepoints. The participants will also be asked to keep a study diary throughout the study period for the documentation of their intestinal health and as a means for checking compliance.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

TRIPLE

Enrollment

Conditions

Low-grade Inflammation Increased Intestinal Permeability

Interventions

Eligibility

Sex: ALLMin age: 75 YearsMax age: 90 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * Age \>75 years * CRP 2-10 mg/L * Ability to fill in a study diary by him/herself Exclusion Criteria: * Intake of antibiotic treatment in the last 4 weeks before inclusion into the study. * Currently on corticosteroid treatment * Presence of chronic inflammatory disease

Outcomes

Primary Outcomes

Reduced intestinal permebility measured as decline in the levels of zonulin in blood samples

Time frame: All blood markers analysed in the study will be measured at start, before the onset of intervention and 4 weeks later at the end of intervention.