Randomized Controlled Trial Methods for Novel Tobacco Products Evaluation

Inclusion Criteria: * Age 21-65 * Smoke \>9 cigarettes per day for at least 1 year * Smoke regular filtered cigarettes or machine-rolled cigarettes with a filter * CO measurement \>9 ppm at baseline * No serious quit attempt in the prior 1 month. This includes use of any FDA approved smoking cessation medication (varenicline, bupropion \[used specifically as a quitting aid\], patch, gum, lozenge, inhaler, and nasal spray) in the past 1 month as an indication of treatment seeking. * Not planning to quit in the next 6 months * Interested in reducing cigarette consumption * Willing to attend visits weekly and monthly over a 9-month period (not planning to move, not planning extended vacation, no planned surgeries) * Read and write in English * Able to understand and consent Exclusion Criteria: * Pregnant and/or nursing women * Unstable or significant medical condition in the past 12 months (Recent heart attack or some other heart conditions, stroke, severe angina including high blood pressure if systolic \>159 or diastolic \>99 observed during screening). * Immune system disorders, respiratory diseases (exacerbations of asthma or COPD, require oxygen, require oral prednisone), kidney (dialysis) or liver diseases (cirrhosis), or any medical disorder/medication that may affect participant safety or biomarker data. * Use of any non-cigarette nicotine delivery product (pipe, cigar, dip, chew, snus, hookah, ECIGs, strips, sticks) in the past 7 days * Uncontrolled mental illness or substance abuse or inpatient treatment for these in the past 6 months * History of difficulty providing or unwilling to provide blood samples (fainting, poor veins, anxiety) * No surgery requiring general anesthesia in the past 6 weeks * Use of an ECIG for 5 or more days in the past 28 days or any use in the past 7 days * Use of marijuana or any illicit drug/prescription drugs for non-medical use daily/almost daily, or weekly in the past 3 months per NIDA Quick Screen * Use of hand-rolled, roll your own cigarettes * Known allergy to propylene glycol or vegetable glycerin * Other member of household is currently participating/participated in the study