The purpose is to investigate the effect of strength training on muscle strength, muscle mass and nutritional status in patients with liver cirrhosis to clarify possible metabolic and inflammatory changes during this intervention. In addition the investigator examine if the intervention is associated with fewer hospital readmission and an improved quality of life.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
SINGLE
Enrollment
39
All participants will receive professional dietary guidance and a protein supplement. At the beginning and end of the intervention every participant will be part of a program consisting of: Test of muscle strength, blood samples, assessment of nutritional status, MRi scan, test of Quality of life by questionnaire and test of the ammonium metabolism. After one year readmissions will by registered. The intervention group will receive supervised training.
All participants will receive professional dietary guidance and a protein supplement. At the beginning and end of the intervention every participant will be part of a program consisting of: Test of muscle strength, blood samples, assessment of nutritional status, MRi scan, test of Quality of life by questionnaire and test of the ammonium metabolism. After one year readmissions will by registered.
Department of Hepatology and Gastroenterology V, Aarhus University Hospital
Aarhus, Denmark
Maximal voluntary muscle strength in knee extensor will be measured by an isokinetic dynamometer and hand strength by hand dynamometer.
Time frame: 12-14 weeks
Nutritional status as measured by Triceps skinfold thickness (TSF), mid-upper-arm circumference (MUAC), mid-arm muscle area (MAMA) and hand dynamometer
Time frame: 12-14 weeks
Readmissions as measured by a follow-up one year after the intervention.
Time frame: 1-1,5 year
Quality of Life as measured by a standardized questionnaire (SF-36)
Time frame: 12-14 weeks
Insulin sensitivity as measured by HOMA-IR
Time frame: 12-14 weeks
Ammonia metabolism as measured by Oral Glutamine Challenge Test
Minimal risk in the taking of blood samples. The participant can experience nausea and dizziness but will not be left unsupervised during the test.
Time frame: 12-14 weeks
Muscle mass as measured by MRi scan and bioimpedance scan.
Time frame: 12-14weeks
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