The Effect of Sucrose on Pain Relief During Venous Blood Sampling in Preterm Infants

Norwegian University of Science and Technology50 enrolled

Overview

Despite the fact that oral sucrose is the most frequently studied non-pharmacological intervention for procedural pain relief in infants, there is a paucity of data on the minimal effective dose. The aim of this study is to find the minimal effective dose of sucrose to reduce pain during a single venous blood sampling procedure.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

DOUBLE

Enrollment

Conditions

Pain

Interventions

0.2 ml sucrose 25%OTHER

Administered on the tongue by a syringe, a half dose two minutes before blood sampling and the other half dose immediately before sampling

0.5 ml sucrose 25%OTHER

Administered on the tongue by a syringe, a half dose two minutes before blood sampling and the other half dose immediately before sampling

Eligibility

Sex: ALLMax age: 8 Weeks

Medical Language ↔ Plain English

Inclusion Criteria: * born preterm * more than 1000 gram Exclusion Criteria: * severe intraventricular hemorrhage * cerebral malformations * other malformations requiring surgery * medication that may impair pain expression (opioids, paracetamol, sedatives)

Locations (2)

St Olavs Hospital

Trondheim, Norway

Lower Umfolozi Rigional War Memorial Hospital, NICU

Empangeni, South Africa

Outcomes

Primary Outcomes

pain

assessed by Premature Infant Pain Profile-Revised (PIPP-R). Pain score related to the blood sampling will be performed two times: at skin puncture and immediately after the needle has been removed

Time frame: 1 week

Data from ClinicalTrials.gov

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