1. To compare the corneal epithelial defect healing time between diabetic patients receiving and not receiving supplementary oxygen after vitrectomy. 2. To determine whether factors such as age, duration of diabetes, duration of surgery and level of glycemic control have any influence on corneal epithelial wound healing time in diabetic patients receiving and not receiving supplementary oxygen post-vitrectomy.
This study aims to determine whether systemic oxygen therapy delivered through face mask would have beneficial effects on the healing of corneal epithelial wound in post-vitrectomy diabetic patients. It will be a prospective, randomised interventional clinical study conducted on diabetic patients indicated for vitrectomy. Rationale of this study is to see if systemic oxygen delivered via face mask will hasten the resolution of corneal epithelial defects, which may either be iatrogenic (surgically-induced intra-operatively to enable clearer visualisation for the surgeon) or spontaneous (due to corneal epithelial fragility which is commoner in diabetics)
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
SINGLE
Enrollment
32
Mean corneal epithelial wound healing time (in days)
Time frame: 1 to 7 days
Age of subject as a factor influencing wound healing time
Time frame: 1-7 days
Glycemic control of subject (measured by glycated hemoglobin, HbA1c)
Time frame: 1-7 days
Duration of surgery and its influence on wound healing time
Time frame: 1-7 days
Duration of diabetes mellitus (measured in years) and its influence on wound healing time
Time frame: 1-7 days
This platform is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional.