Efficacy and Safety of Esarin Gel in Chronic Venous Insufficiency and Varicose Veins

1. Inclusion Criteria: * Patients of both sexes, aged above 20 years old. * The patient has confirmed his/her willingness to participate in the study, after being informed about all the aspects of the study that might be relevant for his/her decision to participate, and has signed and dated the informed consent form, as approved by the Institutional Review Board/ Ethics Committee (IRB/EC). * Presence of chronic venous insufficiency which is rated between functional classes CEAP 0 and 3.(CEAP Classes: C0:no visible or palpable signs of venous disease, C1:telangiectasies or reticular veins. C2 :apparent Varicose veins, C3 :Edema) * Diagnosed with superficial vein thrombophlebitis and have skin reaction by redness, swelling, fever and pain symptoms. 2. Exclusion Criteria: * Known allergy to the product's ingredients * pregnant or breastfeeding * patient is joining to any other clinical trail * Patient has not sign the informed consent form * Deep vein thrombosis * Cellulitis * Stasis dermatitis * The patient is taking non-steroids anti-inflammatory drugs( include oral ,topical creams or patch form)