Plaque Regression and Progenitor Cell Mobilization With Intensive Lipid Elimination Regimen (PREMIER), Phase II

Inclusion Criteria: * Willing and able to provide informed consent (including HIPAA) * Age \>30 years * Presenting with acute coronary syndrome (ACS), manifested as unstable angina or non-ST-elevation myocardial infarction * Referred for clinically-indicated, non-emergent (the procedure is not required to be performed within 3 hours after patient presentation) coronary angiography and PCI with Intravascular Ultrasound with Virtual Histology (IVUS-VH) of target coronary artery for ACS * Successful placement of two large bore IV cannulas in bilateral upper extremities * Fasting (12 hrs.) LDL 70mg/dl while on less than or equal to 80mg Atorvastatin or equivalent dose of other statin, performed at time of admission or prior to PCI. Exclusion Criteria: * Known allergy to aspirin, clopidogrel, statins, or iodinated contrast * Positive pregnancy test, planning to become pregnant, or breast-feeding * Coexisting conditions that limit life expectancy to less than six months or affect patient compliance * Uncontrolled fasting (12 hrs.) triglyceride levels ( 500mg/dl) * Already participating in an investigational device or drug study * History of heparin induced thrombocytopenia (HIT) * Persons with estimated glomerular filtration rate (eGFR) of less than 45 ml/min * ST-elevation myocardial infarction at admission * Abnormal liver function test (LFT) at time of admission or prior to PCI with abnormal LFT defined as any liver transaminases (ALT or AST) 3 times the upper limit of the normal laboratory reference * Pre-PCI or post-PCI left ventricular ejection fraction \<25% by echo or cardiac catheterization done after admission * Pre-PCI, intra-PCI, or post-PCI hemodynamic instability with hypotension * Pre-PCI, intra-PCI, or post-PCI cardiac arrest * Pre-PCI or post-PCI acute heart failure with or without pulmonary edema * Intra-PCI or post-PCI sustained ventricular tachycardia * Complicated PCI, defined as PCI with any of the vascular access complications (large hematoma with lump \> 5 cm or requiring medical treatment; arteriovenous (AV) fistula; pseudo aneurysm requiring treatment; retroperitoneal bleeding), or PCI with any of the procedural complications (abrupt vessel closure; no-reflow phenomenon; new angiographic thrombus; new major dissection with reduced flow; catheter-related thrombus), or PCI requiring further medical treatments (urgent coronary artery bypass graft (CABG); endotracheal intubation; unplanned in-aortic balloon pump; left ventricular assist device (LVAD); covered stent; unplanned temporary pacemaker wire; administration of inotropes; cardiopulmonary resuscitation (CPR)) , or PCI resulting in clinical events (death; stroke; myocardial infarction; stent thrombosis) during or within 24 hours after the index PCI * Post-PCI ongoing chest pain * Post-PCI severe groin pain and hematoma \> 5cm in diameter * Persons whose hemoglobin is less than 9 grams following the index PCI/IVUS procedure, or who experience a drop in hemoglobin of greater than or equal to 2 grams following the procedure * Not able to comply with study protocol as determined by the investigators