A Feasibility Study to Evaluate Safety and Initial Effectiveness of ExAblate Transcranial MR Guided Focused Ultrasound for Bilateral Anterior Capsulotomy in the Treatment of Medication-Refractory MDD

Inclusion Criteria: * Men and women, between 20 and 65 years, inclusive * Diagnosed with nonpsychotic major depressive disorder, single or recurrent episode by DSM-IV-TR Diagnosis of Diagnostic and Statistical Manual of Mental Disorder fourth edition(DSM-IV) MDD as confirmed from clinical history and examination by psychiatrist. * Subjects who are able and willing to give consent and able to attend all study visits * Proof of Refractoriness In current episode: * Depression refractory to adequate trials of medication (Persistence of the major depressive episode to a minimum of 3 adequate depression treatments from at least 3 different treatment categories - SSRIs, TCAs, other antidepressants, lithium addition, irreversible MAO inhibitor, etc.) * Documented resistance to ECT (at least 6 sessions or \<6 treatments if there is clear evidence of inability to tolerate more, or refused, or withdrew consent after ECT was recommended. \- Proof of chronicity * More than 5 years after first episode of MDD * current episode of ≥24-mo duration \&/or recurrent illness with at least a total of 4 lifetime episodes (including current episode ≥12 mos) \- Proof of Severity * HAMD-17 score≥20 * Global Assessment of Function Score\<50 * Designated Ablation Targets can be target by the ExAblate device. Designated Ablation Targets must be apparent on MRI such that targeting can be performed with direct visualization * Able to communicate sensations during the ExAblate MRgFUS treatment * Depression medication regimen is stable for at least 30 days before enrollment Exclusion Criteria: * Subjects with current or previous diagnosis of following psychotic or bipolar disorders: * Subjects has primary or serious(requiring additional treatment) comorbid obsessive compulsive disorder, posttraumatic stress disorder, panic disorder, bulimia, or anorexia in the last year by DSM-IV * Patients exhibiting any behavior(s) consistent with ethanol or substance abuse(aside nicotine) as defined by the criteria outlined in the DSM-IV occurring within a 12 months period * Active suicidal ideation with plan or intent for self harm and made suicide attempt within the past 12 months * Patient meets criteria for personality disorder in the last 12 months by DSM-IV * Patients with unstable cardiac status including: * Unstable angina pectoris on medication * Patients with documented myocardial infarction within six months of protocol entry * Congestive heart failure requiring medication (other than diuretic) * Patients on anti-arrhythmic drugs * Severe hypertension (diastolic BP \> 100 on medication) * Severely impaired renal function (estimated glomerular filtration rate \< 45ml/min/1.73 m2) or receiving dialysis * Patients with standard contraindications for MR imaging such as non-MRI compatible implanted metallic devices including cardiac pacemakers, size limitations, etc. * Known intolerance or allergies to the MRI contrast agent(e.g. Gadolinium or Magnevist) including advanced kidney disease * History of abnormal bleeding and/or coagulopathy * Receiving anticoagulant (e.g. warfarin) or antiplatelet (e.g. aspirin) therapy within one week of focused ultrasound procedure or drugs known to increase risk or hemorrhage (e.g. Avastin) within one month of focused ultrasound procedure * Active or suspected acute or chronic uncontrolled infection * History of intracranial hemorrhage * Cerebrovascular disease (multiple CVA or CVA within 6 months) * Individuals who are not able or willing to tolerate the required prolonged stationary supine position during treatment (can be up to 4 hrs of total table time.) * Symptoms and signs of increased intracranial pressue (e.g. headache, nausea, vomiting, lethargy, and papilledema) * Are participating or have participated in another clinical trial in the last 30 days * Unable to communicate with the investigator and staff. * Presence of any other neurodegenerative disease like Parkinson-plus syndromes suspected on neurological examination. These included: * Multisystem atrophy * Progressive supranuclear palsy * Dementia with Lewy bodies * Alzheimer's disease * Anyone suspected to have the diagnosis of MDD. This includes: psychotic depression, bipolar I or II disorder, mental disorder due to organic factors. * Presence of significant cognitive impairment as determined with a score ≤ 24 on the Mini Mental Status Examination (MMSE) * History of immunocompromise, including patient who is HIV positive * Known life-threatening systemic disease * Patients with a history of seizures within the past year * For the purpose of this study, we consider a significant mood disorder to include any patient who has: * received transcranial magnetic stimulation * received electroconvulsive therapy * Patients with risk factors for intraoperative or postoperative bleeding (platelet count less than 100,000 per cubic millimeter, PT \> 14, PTT \> 36 or INR \> 1.3) or a documented coagulopathy * Patients with any types of brain tumors, including metastases. * Any illness that in the investigator's opinion preclude participation in this study. * Pregnancy or lactation. * Legal incapacity or limited legal capacity. * Patients who have had deep brain stimulation or a prior stereotactic ablation of the Designated Ablation Target. * Prior intracranial surgery * Calcifications in the sonication pathway that cannot be avoided by tailoring the treatment plan * More than 30% of the scalp in the sonication pathway is covered by scars, scalp disorders (e.g., eczema) or atrophy of the scalp * Clips or other metallic implanted objects in the sonication pathway, except shunts.