Non-Interventional Study to Evaluate Safety and Efficacy of NOVOCART 3D in Patients With Cartilage Defects

Inclusion Criteria: * Male and female adult patients * Children and adolescents with closed epiphysial plate * Defect size ≥2.5 and ≤10 cm2 post-debridement * Localized full thickness articular cartilage defect of the knee (Grade 3 \& 4 International Cartilage Repair Society (ICRS) classification) Exclusion Criteria: * Radiologically apparent degenerative joint disease in the target knee as determined by Kellgren and Lawrence grade \>2 * More than 2 defects or 2 corresponding lesions * Ankylosis * Arthrofibrosis * Diffuse chondromalacia * Total/subtotal resected meniscus * Insufficient Ligament guidance * Patella malignement * Inflammatory joint disease * General cartilage degeneration or increased joint deterioration * Cancer, present or within the last 5 years * Primary treatment in children and adolescents with open epiphysial plate * Chronical infection diseases * Untreated coagulation disorder * Pregnancy and lactating * Known history of allergies against ingredients of NOVOCART® 3D