The purposes of the study are to assess intra individual biological variability of serum and urinary cartilage specific biomarkers and define the best standardized conditions for blood and urine sampling in the frame of biomarkers dosage.
To assess intra individual biological variability of serum and urinary cartilage specific biomarkers and define the best standardized conditions for blood and urine sampling in the frame of biomarkers dosage. Variation factors assessed are: * Fasting condition * Sampling time * Sampling season * Physical activity * Duration and temperature of total blood treatment * Type of blood collection tube.
Study Type
OBSERVATIONAL
Enrollment
15
Serum and urine samples will be collected at baseline, weeks2, 16, 52 and 68 to assess intra-individual biological variability of cartilage-specific biomarkers Coll2-1/Coll2-1NO2 / FIB3-1 and FIB3-2.
ATC SA, Unité de pharmacologie clinique, CHU Sart Tilman
Liège, Liege, Belgium
Variation of serum and urine sample between baseline, weeks 2, 16, 52 and 68 to assess intra-individual biological variability of cartilage-specific biomarkers Coll2-1/Coll2-1NO2 / FIB3-1 and FIB3-2.
Change from baseline will be assess by biomarkers dosage using ELISA (Enzyme Linked ImmunoAssay)
Time frame: Baseline and weeks 2, 16, 52 and 68
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