The potential health effects of high intake of lean or fatty fish will be investigated in overweight or obese adults. Participants consume 750g/week of fillets of fish for 8 weeks. Hypothesis: High intake of fatty or lean fish will beneficially affect glucose regulation and the immune system.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
SINGLE
Enrollment
76
Haukeland University Hospital
Bergen, Norway
Changes in serum concentrations of glucose
Time frame: baseline and 8 weeks
Changes in insulin, insulin C-peptide, leukocyte fatty acids, leukocyte function, body weight and composition, and intake of energy and macronutrients within the groups over time.
Time frame: baseline and 8 weeks
Changes in serum vitamin concentrations after fish intake.
Serum concentrations of fat-soluble and water-soluble vitamins were measured, and dietary intakes of vitamins were estimated based on reported food intake from 5-day food diaries.
Time frame: baseline and 8 weeks
Changes in serum and urine concentrations of amino acids and metabolites of amino acids after fish intake.
Concentrations of amino acids and amino acid metabolites were measured in fasting serum and morning urine
Time frame: baseline and 8 weeks
Changes in fecal microbiota profile after fish intake.
54 DNA bacterial markers targeting more than 300 bacteria based on their 16S rRNA sequence in seven variable regions were analysed in feces (72h collection)
Time frame: baseline and 8 weeks
Changes in fecal and serum concentrations of lipids and bile acids after fish intake.
Fat, cholesterol and total bile acids were quantified in feces (72h collection) and fasting serum.
Time frame: baseline and 8 weeks
Changes in markers of oxidative stress after fish intake.
Antioxidant enzymes, antioxidant enzyme cofactors and biomarkers of oxidative stress were quantified in serum
This platform is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional.
Time frame: baseline and 8 weeks
Changes in total neopterin after fish intake
Total neopterin was measured in serum.
Time frame: baseline and 8 weeks
Quantification of markers of kidney dysfunction
Urine concentrations of cystatin C and T-cell immunoglobulin mucin-1 (relative to creatinine) were measured as markers of kidney function
Time frame: baseline and 8 weeks
Changes in amino acids and metabolites of amino acids after a standardized meal.
Concentrations of amino acids and amino acid metabolites were measured in fasting and postprandial serum
Time frame: baseline
Changes in metabolites and co-factors involved in one-carbon metabolism after a standardized meal
Concentrations of relevant metabolites and co-factors were measured in fasting and postprandial serum
Time frame: baseline
Comparisons of amino acid concentrations in serum and urine between men and women
Concentrations of amino acids and amino acid metabolites were measured in serum and urine
Time frame: baseline
Comparisons of metabolites and co-factors involved in one-carbon metabolism in serum and urine between men and women
Concentrations of relevant metabolites and co-factors were measured in serum and urine
Time frame: baseline