Oral Immunotherapy for Peanut and Mammalian Meat Allergies

University of Virginia24 enrolled

Overview

Pilot study to assess the effect of oral immunotherapy on specific Immunoglobulin E (IgE) levels and antigen consumption in two distinct food allergies.

In subjects with mammalian meat allergy, the effect of daily oral cow's milk on immune parameters and desensitization will be assessed. Similarly, in subjects with a peanut allergy the effects of low dose peanut flour will be assessed and comparisons between two distinct food allergies.

Study Type

INTERVENTIONAL

Allocation

NON_RANDOMIZED

Purpose

TREATMENT

Masking

NONE

Enrollment

Conditions

Food Hypersensitivity

Interventions

cow's milkDIETARY_SUPPLEMENT

daily consumption of cow's milk

peanut powderDIETARY_SUPPLEMENT

peanut oral immunotherapy

Eligibility

Sex: ALLMin age: 4 YearsMax age: 80 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * Presence or absence of specific IgE to alpha-gal or peanut Exclusion Criteria: * History of severe anaphylaxis * allergy to cow's milk protein

Locations (1)

University of Virginia

Charlottesville, Virginia, United States

Outcomes

Primary Outcomes

The Level of Allergen Consumed Post-oral Immunotherapy

consumption of cow's milk or peanut flour at open challenge. This is a single time-point assessment; not measured repeatedly.

Time frame: Following 36 months of maintenance oral immunotherapy, participants completed an open challenge at month 37

Data from ClinicalTrials.gov

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