Patritumab With Cetuximab and a Platinum Containing Therapy for Patients With Head and Neck Cancer

Inclusion Criteria: * Histologically or cytologically confirmed recurrent disease or metastatic SCCHN originating from the oral cavity, oropharynx, hypopharynx, and larynx * Has documented disease recurrence following prior treatment * Has Eastern Cooperative Oncology Group (ECOG) performance status 0 or 1 * Has adequate hematological function, per protocol * Has adequate renal function, per protocol * Has adequate hepatic function, per protocol * Has prothrombin time (PT) or partial thromboplastin time (PTT) within 1.5 x upper limit of normal (ULN) * Has a negative serum pregnancy test performed within 14 days prior to enrollment (where required by local regulations, test may be required within 72 hours prior to enrollment), if a woman of child-bearing potential * Agrees to use double-barrier contraceptive measures, oral contraception, or avoidance of intercourse during the study and for 90 days after last study dose received, if of child-bearing potential * Is willing and able to comply with scheduled visits, treatment plan, laboratory tests, and other study procedures Exclusion Criteria: * Has left ventricular ejection fraction (LVEF) \< 50% * Has received prior epidermal growth factor receptor (EGFR) targeted regimen * Has received prior anti-HER2, anti-HER3, or anti-HER4 therapy * Has received prior treatment for recurrent/metastatic disease * Has history of other malignancies, except adequately treated non-melanoma skin cancer, curatively treated in-situ disease, or other solid tumors curatively treated with no evidence of disease for ≥ 5 years * Has known history of and active brain metastases * Has uncontrolled hypertension (systolic \> 160 mm Hg or diastolic \> 100 mm Hg) * Has clinically significant electrocardiogram (ECG) changes * Has had myocardial infarction within 1 year before enrollment, symptomatic congestive heart failure (New York Heart Association \>Class II), unstable angina, or unstable cardiac arrhythmia requiring medication * Had platinum-containing drug therapy/chemotherapy with radiotherapy \< 6 months before study drug treatment * Had therapeutic or palliative radiation therapy or major surgery within 4 weeks before study drug treatment. * Participated in clinical drug trials within 4 weeks before study drug treatment or is currently participating in other investigational procedures * Has uncontrolled infection requiring intravenous (IV) antibiotics, antivirals, or antifungals, known human immunodeficiency virus (HIV) infection, active hepatitis B or C infection, or is undergoing medical treatment for infection * Has uncontrolled type 1 or 2 diabetes mellitus * Has known hypersensitivity or allergic reaction against any of the components of the trial treatment * Is pregnant, breastfeeding, or unwilling/unable to use acceptable contraception * Has psychological, social, familial, or geographical factors that would interfere with study participation or follow up