Adverse Plaque Characteristics in CCTA and TVC Imaging

Inclusion Criteria: 1. Age 20 years of older 2. Patients with typical chest pain or evidences of myocardial ischemia (e.g., stable, unstable angina, silent ischemia and positive functional study or reversible changes in the electrocardiogram (ECG) consistent with ischemia 3. Patients with signed informed consent 4. Confirmed coronary artery disease in computed tomography Exclusion Criteria: 1. The past history of coronary artery disease (e.g., myocardial infarction, percutaneous coronary intervention (PCI), coronary artery bypass graft surgery (CABG), etc.) 2. Less than 2-year life expectancy due to non-cardiac disease 3. If the subject cannot voluntarily agree in writing to participate in this study 4. If the subject is currently participating in any other study with another investigational drug or medical device 5. Allergic reaction to iodinated contrast media 6. Significant renal dysfunction (Serum creatinine \> 1.5 mg/dl) 7 Heart rate ≥ 80 beats per minute even after treatment with a heart rate lowering medication which disable to take CCTA 8\. Contraindications of either β blockers or nitroglycerin 9. The past history of complex congenital heart disease 10. Pregnant women or women with potential childbearing 11. Body mass index (BMI) exceeding 35 12. Irregular heartbeats which disable to take CCTA 13. Contraindications of statin due to hypersensitivity, past history of serious complication such as myopathy or increased liver enzyme more than 3 times of normal upper limit