Preoperative Radiochemotherapy With Hyperthermia for Locally Advanced Rectal Cancer

Inclusion criteria: * Histologically confirmed Adenocarcinoma of the rectum (up to 10 cm from the anal verge) * International Union Against Cancer stages II or III * ECOG PS 0/2 * Informed consent Exclusion Criteria: * Congestive heart failure (NYHA III/IV) * History of myocardial infarction within the last 6 months. * AV Block III * Total hip replacement or major metal pelvic implants * Cardiac pacemaker * Contraindications for radiochemotherapy * Contraindications for surgical tumor resection * Previous pelvic radiotherapy or chemotherapy * Active chronic inflammatory bowel disease * Collagenosis * Congenital diseases with increased radiosensitivity * Pregnancy or breastfeeding * Secondary malignancies other than locally controlled basalioma or in-situ carcinomas Infiltration of the anal canal