Evaluation of Switching From Current cART to Triumeq With Adherence Support Will Enhance HIV Control in Vulnerable Populations

Inclusion Criteria: 1. HIV-1 infected adults greater than or equal to 18 years of age. 2. Prescribed cART that may include any DHHS recommended or alternative regimens, which the treating physician considers, is appropriate for their patient with the exception of dolutegravir 3. Evidence of non-adherence to current ART regimen defined as: 1. HIV RNA ≥400 copies/ml at least once in last 12 months 2. Absence of resistance to current regimen 3. Viremia not explained by normal viral decay after initiating ART 4. Documentation that the subject is negative for HLA-B\*5701 allele 5. Signed informed consent prior to screening. 6. Women who are suspected, planning to become or pregnant or breastfeeding must have a negative pregnancy test at screening and Day 1 and agree to use the following approved methods of birth control while on study. A female, may be eligible to enter and participate in the study if she: 1. is of non-child-bearing potential defined as either post-menopausal (12 months of spontaneous amenorrhea and ≥ 45 years of age) or physically incapable of becoming pregnant with documented tubal ligation, hysterectomy or bilateral oophorectomy or, 2. is of child-bearing potential with a negative pregnancy test at both Screening and Day 1 and agrees to use one of the following methods of contraception to avoid pregnancy: * Complete abstinence from penile-vaginal intercourse from 2 weeks prior to administration of IP, throughout the study, and for at least 2 weeks after discontinuation of all study medications; * Double barrier method (male condom/spermicide, male condom/diaphragm, diaphragm/spermicide); * Any intrauterine device (IUD) with published data showing that the expected failure rate is \<1% per year (not all IUDs meet this criterion * Male partner sterilization confirmed prior to the female subject's entry into the study, and this male is the sole partner for that subject; * Approved hormonal contraception * Any other method with published data showing that the expected failure rate is \<1% per year. Any contraception method must be used consistently, in accordance with the approved product label and for at least 2 weeks after discontinuation of Triumeq. 7. Heterosexual men should use at least one barrier method of contraception (e.g. condom) Exclusion Criteria: 1. Not meeting inclusion criteria 2. Women who are pregnant or breastfeeding 3. Any evidence of an active Centers for Disease and Prevention Control (CDC) Category C disease25 except cutaneous Kaposi's sarcoma not requiring systemic therapy 4. Subjects with moderate to severe hepatic impairment (Class B or C) as determined by Child-Pugh classification 5. Anticipated need for Hepatitis C virus (HCV) therapy during the study 6. Chronic hepatitis B infection (defined as HBsAg positive) 7. History or presence of allergy or intolerance to the study drugs or their components or drugs of their class 8. Any evidence of viral resistance to 3TC, abacavir or integrase inhibitors or to any component of the current regimen based on the presence of primary resistance-associated mutations for these drugs26 on any available historical resistance test. 9. Any evidence of viral resistance to 3TC, abacavir or integrase inhibitors or to any component of the current regimen based on the presence of primary resistance-associated mutations for these drugs26 on a screening genotype for patients with HIV RNA ≥400 copies/ml . 10. Any acute laboratory abnormality at Screening, which, in the opinion of the Investigator, would preclude the subject's participation in the study 11. Alanine aminotransferase (ALT) greater than 5 times the upper limit of normal, OR ALT greater than or equal to3 times the upper limit of normal and bilirubin greater than or equal to1.5 times the upper limit of normal (with greater than 35% direct bilirubin) 12. Creatinine clearance of less than 50 mL/min via Cockroft-Gault method 13. Concomitant medications, dofetilide and immunosuppressants.