COPD is characterized by exagerated decline FEV1 related to obstructive non reversible airflow. This could be the consequence of structural changes and inflammatory pattern of the bronchial wall. Lesions could lead to normal but also abnormal remodeling specially in COPD including a decrease in Club cells number and function.There is no treatment actually available targeted to a normal repair of the epithelium. The objective of this work is to identify potential targets for reprograming bronchial epithelial cells I order to achieve a good repair.
Study Type
INTERVENTIONAL
Allocation
NA
Purpose
BASIC_SCIENCE
Masking
NONE
Enrollment
30
Pneumology Department
Montpellier, France
Full recovery one day after injury (yes / no) proportion of cells showing the repair, remodeling or regeneration of the epithelium (ciliated cells, mucus cells, Clara cells) in culture in air-liquid interface in the three groups
The study will be judged on the proportion of cells showing the repair, remodeling or regeneration of the epithelium (ciliated cells, mucus cells, Clara cells) in culture in air-liquid interface in the three groups.
Time frame: 1 day
Measurement of apoptosis and inflammation (IL8)
Determine the molecular mechanisms and deleterious cell leading to poor repair of the epithelium in patients with COPD
Time frame: 24 months
Measure the effect of the CC10 protein secreted by Clara cells on the repair of the bronchial epithelium.
Measuring the reprogramming of the epithelium of COPD patients to a control-type epithelium
Time frame: 24 months
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