Antioxidants in Gestational Diabetes

Cairo University200 enrolled

Overview

Fasting and two hours postprandial blood sugar were done to all cases between 28 and 32 weeks and high blood sugar levels were found so Cases were controlled by both diet and insulin. The 200 pregnant women with Gestational diabetes mellitus were randomized using automated web based randomization system into 2 groups, Group1 received 1 gram L-ascorbic acid (vitamin C )per day from the time of diagnosis until the time of delivery in addition to routine treatment of diabetes (diet \& insulin). Group2 received only the treatment of diabetes

The 200 pregnant women with Gestational diabetes mellitus were randomized using automated web based randomization system into 2 groups, Group1 received 1 gram L-ascorbic acid oral once daily (vitamin C )per day from the time of diagnosis until the time of delivery in addition to routine treatment of diabetes (diet \& insulin). Group2 received only the treatment of diabetes (diet and insulin

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

PREVENTION

Masking

NONE

Enrollment

200

Conditions

Gestational Diabetes Mellitus

Interventions

L-ascorbic acidDRUG

1 gram L-ascorbic acid (vitamin C …..) per day from the time of diagnosis until the time of delivery

Eligibility

Sex: FEMALEMin age: 20 YearsMax age: 40 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Women with the diagnosis of GDM Exclusion Criteria: * Women with multiple pregnancies * Chronic medical disorders e.g. anemia * Hypertension * Liver disease or renal disease * Those with obstetric problems other than GDM (e.g. pre-eclampsia \& antepartum hemorrhage) or smokers and women with preexisting type I or II diabetes mellitus were excluded from our study

Locations (1)

Kasr Alainy medical school

Cairo, Cairo Governorate, Egypt

Outcomes

Primary Outcomes

neonatal outcome assessed by neonatal ICU admission

Time frame: 1 week after delivery

Secondary Outcomes

oxidative stress parameters: non enzymatic and enzymatic oxidative stress parameters in placental tissue homogenates in women with GDM named glutathione ,malondialdahyde,superoxide dismutase ,catalase and glutathione peroxidase

Time frame: 9 months of pregnancy

oxidative stress parameters: non enzymatic and enzymatic oxidative stress parameters in maternal blood plasma/lysate in women with GDM named glutathione,superoxide dismutase ,catalase and glutathione peroxidase

Time frame: 9 months of pregnancy

oxidative stress parameters: non enzymatic and enzymatic oxidative stress parameters in neonatal blood in women with GDM named malondialdahyde and superoxide dismutase

Time frame: 9 months of pregnancy

Data from ClinicalTrials.gov

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