The primary aim of the study is to investigate new cardiac biomarkers and algorithms to diagnose acute coronary syndrome in patients with suspected acute myocardial infarction.
The primary aim of the study is to detect and evaluate new cardiac biomarkers, evaluate and improve acute coronary syndrome (ACS) risk scores, which takes into account clinical, gender specific, psycho-social and lifestyle-risk factors, protein patterns and genetic variability in addition to the classical risk factors with respect to the primary endpoint of acute myocardial infarction. Secondary study aims are : * To provide estimates for the incidence of ACS in patients presenting with recent onset chest pain; * To provide accurate, quantifiable measures of precursors of ACS; * DNA, RNA, cells, and serum/plasma for comprehensive genetic, gene expression and proteomic studies * To explore the impact of ACS candidate genes on cardiovascular risk stratification by using genome-wide analyses and a biological systems approach; * To explore proteins relevant for ACS; * To allow the identification of new therapeutic targets; * To evaluate the impact of socio-economic factors on ACS and CAD risk. Patients will be followed up during the hospital stay. Afterwards a telephone follow-up will take place after 30 days, 6, 24 and 48 months.
Study Type
OBSERVATIONAL
Enrollment
5,000
Department of Cardiology, University Heart Center Hamburg
Hamburg, Germany
RECRUITINGAcute myocardial infarction as index event
The primary endpoint of the study is acute myocardial infarction
Time frame: Months
AMI, Mortality, heart failure and quality of life
The secondary endpoint of the study is mortality, heart failure, quality of life.
Time frame: Years
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