EFFORT Asthma: Effects of Diet and Exercise in Asthma

University of Copenhagen149 enrolled

Overview

This project aims to study the effects of lifestyle changes on asthma and systemic inflammation in a randomized clinical trial of diet and exercise. The project is a multidisciplinary collaboration in the areas of medicine, physiology and nutrition, centred on improving asthma control in non-obese sedentary asthmatics via simple means.

After screening and enrollment, a total of 200 Danish sedentary, non-obese asthma patients will be randomized to one of four groups: 1) control group (no intervention), 2) physical exercise intervention, 3) diet intervention (a diet with an overall high content of protein and a low glycemic index) or 4) exercise plus diet intervention. Asthma is defined as respiratory symptoms and at least one positive asthma test. Patients will continue their regular doses of anti-asthma treatment unchanged throughout the study period. Type of anti-inflammatory medicine will be recorded and the adherence to the therapy will be assessed before the intervention period and at follow-up using questionnaires

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

SINGLE

Enrollment

149

Conditions

Asthma

Interventions

ExerciseBEHAVIORAL

Aerobe exercise 3 times a week in 8 weeks

DietBEHAVIORAL

Diet (a diet with an overall high protein content and a low glycemic index) in 8 weeks

Eligibility

Sex: ALLMin age: 18 YearsMax age: 65 Years

Medical Language ↔ Plain English

Inclusion Criteria: * \>18 years old * Uncontrolled or partly uncontrolled asthma * Capable of exercising on bike * Sedentary (currently do less than 60 min of structured/planned physical activity per week) Exclusion Criteria: BMI ≥ 30.0 or \<20.5 * Chronic obstructive pulmonary disease (COPD), pregnancy, other inflammatory or metabolic diseases * The use of oral anti-inflammatory medication or the use of antibiotic treatment during the last 8 weeks.

Locations (1)

Respiratory Research Unit, Birpebjerg Hospital

Copenhagen NV, Denmark