Study of the Cutaneous Reinnervation After Burn

University Hospital, Brest6 enrolled

Overview

The aim of this study is to understand why the regeneration of the cutaneous sensory nerve fibers is poor in post-burn scar. The presence or the lack of several molecular factors known to regulate neuronal cell development will be evaluate and compared within biopsies from healthy skin and post-burn scar.

Study Type

INTERVENTIONAL

Allocation

Masking

NONE

Enrollment

Conditions

Post-burn Innervation

Interventions

Skin biopsyPROCEDURE

2 biopsies are done on the same patient : 20 cutaneous biopsies from post-burn scar and from healthy skin

Eligibility

Sex: ALLMin age: 18 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Major patients * At least one year back deep burn (2nd and 3rd degrees), and allowing the comparison between the post-burn scar dermatome and the healthy opposite dermatome * Patients always followed in the service of Plastic surgery of the hospital of Brest * Informed consent and paper of the patient after information of the objective of the study and the protocol * Analog Visual scales for pain and/or pruritus (EVA): greater than or equal to 3 * Simple Verbal scales for the pain and/or the pruritus ( EVS): pain / pruritus moderated to intense * Membership to the Social Security Exclusion Criteria: * Allergy to xylocaine * Non-Caucasian patients * Treatments having an effect on the pain and/or the pruritus * Sun or UV exposure several days preceding or following the biopsies

Locations (1)

CHRU de Brest

Brest, France, France

Outcomes

Primary Outcomes

Number of the differences of expression of genes coding for regulating proteins of the innervation

To evaluate the differences of expression of genes coding for regulating proteins of the innervation on samples of healthy skins and post-burn scar. These biopsies will be removed from post-burn patients (at least one year after burn) and allowing the comparison between conflicting dermatomes: a healthy dermatome and a formerly burned dermatome

Time frame: 6 months

Secondary Outcomes

Validation of the difference of density of intra-epidermic nerve fibers

To validate the existence of a difference of density of intra-epidermal nerve fibers between the healthy skins and the post-burn scar.

Time frame: 6 months

Data from ClinicalTrials.gov

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