Hyperbaric VO2max Study

Phase 2TerminatedNCT02356900

Duke University25 enrolled

Overview

This study seeks to examine the effectiveness of training while in a hyperoxic-hyperbaric environment for exercise performance at altitude. Subjects will complete a short, high-intensity interval training (HIT) program inside the hyperbaric chamber.Before and after this training phase, all subjects will be tested for maximum aerobic capacity at a simulated high altitude of 15,000ft in a hypobaric chamber, as well as for molecular markers of mitochondrial oxidative capacity in a skeletal muscle biopsy. A group of individuals of similar characteristics completing this training program in a normoxic-normobaric environment will serve as a control.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

OTHER

Masking

NONE

Enrollment

Conditions

Exercise Training

Interventions

Hyperoxic hyperbaric interval exercise trainingPROCEDURE

Six 30-min high-intensity interval training sessions completed 3-times a week while at 1.4 ATA of oxygen in a hyperbaric chamber.

Normoxic, normobaric, interval exercise trainingPROCEDURE

Six 30-min high-intensity interval training sessions completed 3-times a week.

OxygenDRUG

Used in Hyperoxic hyperbaric interval exercise training intervention

Eligibility

Sex: ALLMin age: 18 YearsMax age: 35 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * healthy, recreationally active or sedentary individuals Exclusion Criteria: * VO2max \< 35 ml/kg/min - male 30 ml/kg/min - female * chronic cardiovascular or pulmonary diseases * history of pneumothorax * active smoker * pregnant women * non-english speaking * not in full mental capacity * blind * sickle cell trait or disease

Locations (1)

Duke University Hospital

Durham, North Carolina, United States

Outcomes

Primary Outcomes

Change in Maximum Aerobic Capacity (VO2max) From Baseline to Post-training (< 72 Hours )

Graded exercise test to exhaustion at simulated 15000 ft altitude

Time frame: Baseline and <72 hrs Post-training

Change in Ventilatory Threshold (VT) From Baseline to Post-training (<72 Hours)

Graded exercise test to exhaustion at simulated 15000 ft altitude

Time frame: Baseline and <72 hrs Post-training

Mitochondrial Mass Change

Immunofluorescence microscopy using citrate synthase staining