Genetics of Uveitis

The Cleveland Clinic1,500 enrolled

Overview

In order to improve the investigators knowledge about uveitis and the underlying mechanism of disease, the investigators propose collecting blood from patients with uveitis, isolating DNA and sequencing the DNA to identify genetic mutations or associations in these patients.

Study Type

OBSERVATIONAL

Enrollment

1,500

Conditions

Uveitis Infectious Uveitis

Eligibility

Sex: ALLMin age: 6 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * Any patient above with the diagnosis of uveitis. * Any patient with a diagnosis of infectious uveitis such as toxoplasmosis retinochoroiditis, herpes associated retinitis. Exclusion Criteria: * Patients who are unable to give consent * Patients in whom an adequated blood sample can not be obtained.

Locations (1)

Cleveland Clinic Foundation

Cleveland, Ohio, United States

RECRUITING

Outcomes

Primary Outcomes

Non infectious uveitis

Distinct uveitis conditions will have a polymorphism association or specific mutation.

Time frame: 5 years

Secondary Outcomes

Infectious uveitis

Infectious uveitis (such as herpes associated uveitis, toxoplasmosis retinochoroiditis) will have specific polymorphisms/mutations in innate immune system genes which predispose the patient to infectious uveitis.

Time frame: 5 years

Central Contacts

Kimberly M Baynes, BSN, RN, COA

CONTACT

216-444-2566 baynesk@ccf.org

Data from ClinicalTrials.gov

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