Mortality Reduction in Septic Shock by Plasma Adsorption

Francisco Colomina Climent55 enrolled

Overview

The study objective is to clarify whether the application of high doses CPFA (Coupled Plasma-Filtration Adsorption) in addition to the current clinical practice is able to reduce hospital mortality in septic shock patients in intensive care unit (ICU).

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

OTHER

Masking

NONE

Enrollment

Conditions

Septic Shock

Interventions

High Doses CPFADEVICE

Eligibility

Sex: ALLMin age: 18 Years

Medical Language ↔ Plain English

Inclusion Criteria: * all patients admitted to the ICU in septic shock * all patients that develop septic shock while in the ICU Exclusion Criteria: * Age less than 18 years * Pregnancy * Estimated life expectancy (due to comorbidities) less than 90 days * Presence of relative or absolute contraindications to CPFA * Absence of informed consen

Locations (10)

Hospital de Vinalopó

Elche, Alicante, Spain

Hospital de la Vega Baja

Orihuela, Alicante, Spain

Hospital Universitario de San Juan de Alicante

Sant Joan d'Alacant, Alicante, Spain

Hospital de Torrevieja

Outcomes

Primary Outcomes

Hospital mortality

Time frame: 28 days

Secondary Outcomes

time resolution of septic shock

normalization of lactate, and the decrease in vasoactive drugs

Time frame: within the first 28 days

Data from ClinicalTrials.gov

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