This project tend to investigate the affection of ketone bodies on brain metabolism. This will be done by measuring human cerebral uptake of energy substrates, together with functional parameters, using PET imaging and appropriate radiotracers under hyperketonemia in healthy subjects by ketone infusion. Hypotheses 1. Increased levels of ketone bodies in healthy subjects leads to decreased glucose uptake by brain cells contributing to hyperglycaemia. 2. Increased levels of ketone bodies in healthy subjects leads to increased cerebral blood flow. 3. Altered oxygen consumption during hyperketonemia in healthy subjects.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
BASIC_SCIENCE
Masking
SINGLE
Enrollment
9
3-OHB is infused intravenously.
Saline infusion.
Aarhus University Hospital
Aarhus, Denmark
Glucose metabolism in brain, CMR
cerebral glucose metabolism measured by PET tracer during the above time frame
Time frame: t=240-360 minutes
Stress metabolism
growth hormone, cortisol, glucagon, adrenalin, ghrelin.
Time frame: 0-360 minutes
Oxygen use
cerebral oxygen consumption measured by PET tracer during the above time frame
Time frame: T=150-200 minutes
cerebral blood flow
cerebral blood flow measured by PET tracer during the above time frame
Time frame: t=180-250 minutes
Intramuscular signaling
protein and insulin signaling in muscle
Time frame: t= 260 minutes
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