This study will evaluate the differences in cardiovascular parameters between women with severe preterm preeclampsia and those without preeclampsia using echocardiography and maternal blood. The investigators will also look at associations of abnormal cardiovascular findings and immediate complications among a high risk cohort of pregnant African American women.
This will be a prospective cohort study. Exposed cases will be admitted to the inpatient obstetrical unit (labor \& delivery or antepartum unit) at the Hospital of the University of Pennsylvania with concern for severe preterm preeclampsia. Unexposed controls will be matched by gestational age and other clinical factors and will be obtained from the outpatient setting (Helen O Dickens clinic or Penn ObGyn Associates at 3701 Market Street). The investigators will compare cardiovascular risk factors between these two groups.
Study Type
OBSERVATIONAL
Enrollment
192
Hospital of the University of Pennsylvania
Philadelphia, Pennsylvania, United States
Cardiovascular parameters obtained on echocardiogram (longitudinal strain and E/E)
Time frame: 2 years
Angiogenic factors and biomarkers of congestive heart failure (sFlt1)
Time frame: 2 years
Other cardiovascular parameters measured on echocardiogram (ventricular arterial coupling, arterial tonometry)
Time frame: 2 years
Other angiogenic factors and biomarkers of CHF (VEGF, BNP, troponin, etc)
Time frame: 2 years
Postpartum readmission rate
Time frame: 2 years
Pulmonary edema during labor and delivery or postpartum
Time frame: 2 years
Peripartum cardiomyopathy
Time frame: 2 years
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