Assessment of V0018 2.5 mg Effect on Craving

Inclusion Criteria: * Male and female aged 18 to 64 years * Smoking ≥ 20 cigarettes/day continuously for the last two years * With a first cigarette smoked within 30 min after waking * Not currently in the process of quitting smoking Exclusion Criteria: Related to pathologies * Current or recurrent buccal lesions which, in the opinion of the investigator, would interfere with the assessment of the different parameters * Hyposalivation or asialia * Intolerance to lactose, or any pathology that could cause endogenous production of carbon monoxide (CO) Related to treatments * Use of antidepressants within the last three months * Use of sedatives, hypnotics, tranquilizers or any other addictive agents within the last 3 months * Routine use of tobacco other than cigarettes * Regular use for more than one week of any treatment for smoking cessation (gum, patch, inhaler, lozenge, tablet, bupropion, varenicline) and other smokeless tobacco products (including e-cigarettes) within three months * History of hypersensitivity to nicotine, peanut, soya or to any of the excipients of study treatment * Intolerance to fructose * History of phenylketonuria (aspartame) For women of childbearing potential: * Is pregnant or in post-partum period or a nursing mother