The purpose of this study is to evaluate the efficacy of ASP8232 in reducing Urinary Albumin to Creatinine Ratio (UACR) in subjects with Type 2 Diabetes Mellitus (T2DM) and Chronic Kidney Disease (CKD) at 12 weeks compared to placebo.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
TRIPLE
Enrollment
125
Mean change of log transformed urinary albumin to creatinine ratio (UACR) from baseline to end of treatment
Time frame: Baseline and end of treatment (12 weeks)
Proportion of subjects with either >30% or >40% or >50% reduction in UACR from baseline to end of treatment
Time frame: Baseline and end of treatment (12 weeks)
Mean change of log transformed albumin excretion rate (AER) from baseline to end of treatment
Time frame: Baseline and end of treatment (12 weeks)
Proportion of subjects with either >30% or >40% or >50% reduction in AER from baseline to end of treatment
Time frame: Baseline and end of treatment (12 weeks)
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