Genetic Variation and Variability in Posaconazole Pharmacokinetics in Children

Inclusion Criteria: 1. Age 2 years to under 18 years 2. Weight ≥10 kg 3. Diagnosis of any of the following: any malignancy (e.g., acute myelogenous leukemia \[AML\], acute lymphoblastic leukemia \[ALL\], lymphoma, solid tumor malignancy), hemophagocytic syndrome, bone marrow failure syndrome (e.g., myelodysplastic syndrome and aplastic anemia), hematopoietic stem cell transplantation (HSCT) recipient, or primary immune deficiency with a neutrophil or T-cell defect (e.g., chronic granulomatous disease, hyper IgE syndrome, severe combined immune deficiency). Exclusion Criteria: 1. A female subject must not be pregnant, intend to become pregnant during the study, or breastfeed 2. A subject must not be receiving any of the following medications within 24 hours before or after posaconazole infusion (or according to standard of care protocols): sirolimus, everolimus, pimozide, quinine, HMG-CoA reductase inhibitors primarily metabolized through CYP3A4 (e.g., atorvastatin, lovastatin, simvastatin), ergot alkaloids (ergotamine, dihydroergotamine), methadone, astemizole, cisapride, halofantrine, salmeterol, or vincristine. Potential enrollees will be screened for additional concomitant medications that pose serious safety concerns when given concomitantly to posaconazole. Any of these medications will be an exclusion criterion, unless the concomitant medications may be held for 24 hours before and after posaconazole infusion or according to standard of care protocols 3. A subject must not be receiving any of the following medications concomitant (within 5 half-lives prior) to posaconazole infusion or PK sampling: rifampin, rifapentine, rifabutin, phenytoin, efavirenz, fosamprenavir, or cimetidine. Potential enrollees will be screened for additional concomitant medications that may affect posaconazole metabolism. Any of these medications will be an exclusion criterion, unless the concomitant medications may be held for 5 half-lives prior to posaconazole infusion and through PK sampling 4. A subject must not have moderate or severe liver dysfunction (except in chronic cases as judged by the P.I.) at Baseline, defined as: * A subject must not have moderate or severe liver dysfunction at Baseline, defined as: Aspartate aminotransferase (AST) \> 5 times the upper limit of normal (ULN), OR * Alanine aminotransferase (ALT) \> 5 times the ULN, OR * Serum total bilirubin \>2.5 times the ULN, OR 5. A subject must not have an electrocardiogram (ECG) with prolonged age, sex-adjusted QTc interval. 6. A subject must not have a history of dysrhythmia. 7. A subject must not have creatinine clearance levels (measured or calculated) below 50 mL/min/1.73 m2. 8. A subject must not have a history of Type 1 hypersensitivity or idiosyncratic reactions to azole agents.