Use of IMSI in Poor Responders to IVF

Centro de Infertilidad y Reproducción Humana10 enrolled

Overview

This is a pilot study which aims to determine the role of IMSI in poor responders.

This is a pilot study which aims to determine the role of IMSI over ICSI in poor responders to IVF, without a background of teratozoospermia.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

DOUBLE

Enrollment

Conditions

Female Infertility

Interventions

Intra-cytoplasmic Sperm InjectionPROCEDURE

Selection of sperm at 400x for sperm injection

Intra-cytoplasmic Morphologically-selected Sperm InjectionPROCEDURE

Selection of sperm at 6000x for sperm injection

Eligibility

Sex: FEMALEMin age: 37 YearsMax age: 45 Years

Medical Language ↔ Plain English

Inclusion Criteria: * poor ovarian response Exclusion Criteria: * body mass index (BMI) ≥ 30 kg/m2 * presence of endocrinopathies (e.g., diabetes, hyperprolactinemia, hypothyroidism) * altered karyotype or documented genetic defects in one or both partners * history of chronic, autoimmune or metabolic diseases * altered meiosis in testicular biopsy or altered sperm-FISH * teratozoospermia * participation, simultaneously or within the previous 6 months, in another clinical trial with medication

Locations (1)

Centro de Infertilidad y Reproducción Humana (CIRH)

Barcelona, Spain

Outcomes

Primary Outcomes

Clinical pregnancy rate

Percentage of patients presenting with presence of an intrauterine gestational sac with embryonic cardiac activity display, evaluated by ultrasound, per cycle initiated

Time frame: Four to six weeks after embryo transfer

Secondary Outcomes

Number of embryos obtained

Total number of embryos obtained

Time frame: Two days after egg retrieval

Percentage of cycles with embryo transfer

Number of cycles reaching embryo transfer per cycle initiated

Time frame: Two days after egg retrieval

Data from ClinicalTrials.gov

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