Vestibular Pain Interactions

University of Zurich26 enrolled

Overview

The goal is to establish the practical usefulness of vestibular stimulation for modulating pain perception and to describe the possible mechanisms that could underlie neural vestibular-somatosensory interactions.

Study Type

INTERVENTIONAL

Allocation

NON_RANDOMIZED

Purpose

DIAGNOSTIC

Masking

NONE

Enrollment

Conditions

Healthy

Interventions

Quantitative sensory testingPROCEDURE

Measurement of warm and cold detection and pain thresholds

CHEPSPROCEDURE

Measurement of amplitude and latency of cortically evoked potentials

3D TurntablePROCEDURE

Vection stimulation

Eligibility

Sex: MALEMin age: 18 YearsMax age: 60 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * Weight: 50 - 100 kg * Height: 155 - 185 cm * Male subjects 18 years to 60 years of age * Sufficient command of German language * Written informed consent by the participant after information about the project * Without any known history of neurological disease (especially motor, somatosensory disorders, peripheral neuropathies). * Right-handedness Exclusion Criteria: 1. Intellectually or mental impaired subjects 2. Drug abuse 3. Chronic alcohol consumption 4. No use of marihuana 24h before measurements. 5. No history of vestibular or auditory disorders. 6. Diabetes mellitus 7. Participants of other studies during study period and 30 days prior to study begin 8. Any regular concomitant medication 9. Abnormal QST parameters at the baseline measurement. 10. Absent CHEPs-Potentials at the baseline measurement.

Locations (1)

University hospital Zurich

Zurich, Canton of Zurich, Switzerland

Outcomes

Primary Outcomes

Pain thresholds

The change in heat or cold pain threshold after physical vestibular stimulation and vection stimulation

Time frame: After study inclusion, Day1

Data from ClinicalTrials.gov

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