Vitamin D Improves Depression in Liver Patients

Overview

This study evaluates the efficacy of vitamin D replacement therapy in reducing depressive symptoms in patients with chronic liver disease and vitamin D deficiency. Patients with normal vitamin D levels will be monitored as controls, and they will not receive any intervention.

Patients with chronic liver diseases regularly suffer from vitamin D deficiency and depression. A recent meta-analysis reported an inverse correlation between depression and vitamin D levels. Indeed, vitamin D receptor is present and genomic and nongenomic vitamin D receptor-mediated signalling has been described in brain. This intervention study investigates whether vitamin D therapy ameliorates depressive symptoms in chronic liver disease patients. The investigators hypothesise that depressive symptoms will improve upon vitamin D replacement therapy.

Conditions

Interventions

Eligibility

Locations (1)

Outcomes