Hyper-Thermia Enhanced Anti-tumor Efficacy of Trabectedin

Inclusion Criteria: * Age \> 18 years * Histologically confirmed STS (primary or recurrent), except: Ewing sarcoma, osteosarcoma, skeletal chondrosarcoma (extraskeletal chondrosacomas are included), GIST, dermatofibrosarcoma protuberans, malignant mesothelioma, rhabdomyosarcoma * Patients after failure of first-line chemotherapy (anthracyclines with/without ifosfamide) with or without RHT * Progressive or recurrent tumor which is unresectable or only resectable with adverse functional outcome * After macroscopic incomplete resection or marginal resection (tumor-free margins \< 1 cm) * Prior chemotherapy, including anthracyclines with/without ifosfamide (with or without RHT) or patients who cannot be given these medicines * At least one tumor manifestation which is eligible for hyperthermia * Performance status (ECOG) 0,1 or 2 * More than 3 weeks from last treatment * Neutrophil count ≥ 1,5 G/l, hemoglobin ≥ 9 g/dl, platelets ≥ 100 G/l * Albumin ≥ 25 g/l, total bilirubin ≤ 1 x ULN, ALT/AST ≤ 2.5 x ULN, AP ≤ 2.5 x ULN, Cockroft and Gault's calculated creatinine clearance ≥ 30 ml/min, CPK ≤ 2.5 x ULN * Patients with the ability to follow study instructions and likely to attend and complete all required visits * Written informed consent of the subject Exclusion Criteria: * Uncontrolled infection (e.g. active viral hepatitis) * Unstable cardiac status * Peripheral neuropathy \> grade 2 * Known or persistent abuse of medications, drugs or alcohol * Other malignancy during the last 5 years (exclusion of basal cell carcinoma or adequately treated cervical carcinoma in situ) * Prior therapy with Tr or known history of hypersensitivity to drugs with a similar chemical structure * Pregnancy or breast-feeding * Females of childbearing potential, who are not using and not willing to use medically reliable methods of contraception for the entire study duration * Uncontrolled CNS-metastases * Medical or technical impossibility for hyperthermia to heat the major target lesion