Kefir on Bone Mineral Density and Bone Metabolism in Osteoporotic Patients

Ministry of Science and Technology, Taiwan69 enrolled

Overview

In a controlled, parallel, double-blind intervention study over 6 months, the investigators investigated the effects of kefir-fermented milk (1,600 mg/kg) supplemented with calcium bicarbonate (CaCO3, 1,500 mg/kg) and bone metabolism in 40 osteoporosis patients, and compared them with CaCO3 alone without kefir supplements. Bone turnover markers were measured in fasting blood samples collected before therapy and at 1, 3, and 6 months. BMD values at the spine, total hip, and hip femoral neck were assessed by dual-energy x-ray absorptiometry (DXA) at baseline and at 6 months.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

DOUBLE

Enrollment

Conditions

Osteoporosis

Interventions

PlaceboOTHER

Placebo daily for 6 months

CaCO3OTHER

CaCO3 daily for 6 months

KefirOTHER

Kefir daily for 6 months

Eligibility

Sex: ALLMin age: 55 YearsMax age: 70 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * Clinical diagnosis of osteoporosis patients Exclusion Criteria: * Any previous use of parathyroid hormone or sodium fluoride, use of anabolic steroids or growth hormone within 6 months before trial entry or oral or intravenous systemic corticosteroids within 12 months, and any previous use of strontium.

Outcomes

Primary Outcomes

bone mineral density and bone regeneration

Time frame: 3 months

Data from ClinicalTrials.gov

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