Individualized PEEP Setting by EIT in Patients With ARDS

Peking Union Medical College Hospital126 enrolled

Overview

The investigators conducted a pilot study to compare the effect of Positive End Expiratory Pressure(PEEP) setting guide by lung electrical impedance tomography(EIT) and ARDS-net PEEP-FiO2 table on survival in subjects with mild/severe Acute Respiratory Distress Syndrome(ARDS).

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

NONE

Enrollment

126

Conditions

the PEEP Setting of ARDS

Interventions

the EIT guide the individualized PEEP SettingOTHER

the EIT guide the individualized PEEP Setting in the EIT group

Eligibility

Sex: ALLMin age: 18 YearsMax age: 85 Years

Medical Language ↔ Plain English

Inclusion: 1. acute respiratory distress syndrome with ratio of partial pressure of arterial oxygen over fraction of inspired oxygen (PaO2:FiO2)\<300 and PEEP \>5cmH2O 2. Body mass index \< =40 3. Written inform consent Exclusion: 1. pregnant，intracranial hypertension 2. left ventricular dysfunction (EF\<25% ) 3. Patients with end-stage conditions(death expected within 90 days)

Locations (1)

Department of Critical Care Medicine, Peking Union Medical College Hospital, Peking Union Medical College, Chinese Academy of Medical Sciences,

Beijing, Beijing Municipality, China

Outcomes

Primary Outcomes

survival

Non-survive and survive

Time frame: 28-day

Arterial oxygenation

PaO2(mmHg) measured by blood gas analysis

Time frame: 72h

Secondary Outcomes

length of ICU stay and mechanical ventilated day

Days of ICU stay and received mechanical ventilation(day)

Time frame: 28days

pneumothorax requiring chest tube during first 7 days; barotrauma during first 7 days;

new-onset of pneumothorax and barotrauma

Time frame: 7days

Data from ClinicalTrials.gov

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