Dabigatran in an Interaction Probe Drug Cocktail

Inclusion Criteria: * Healthy * Weight at least 50 kg and body mass index 19 - 30 kg m-2 * Normal clinical laboratory profiles * No childbearing potential or use of adequate contraceptive measures Exclusion Criteria: * Blood loss \>300 ml within 2 months prior to the first dosing day * Pregnancy, breastfeeding * Allergy or hypersensitivity to caffeine, diclofenac, esomeprazole, metoprolol, midazolam, dabigatran or clarithromycin or to excipients in the pharmaceutical products * Infection with HIV, HBV or HCV * Participation in the preceding 3 months or concomitantly in any clinical drug study * Suspected current drug or alcohol abuse * History of drug or alcohol abuse. * Concomitant medication with the exception of hormonal contraception. * Positive result in urine test for drug abuse. * Nicotine consumption equivalent to \>5 cigarettes per day