To date, several studies have been done to explore the relationship between Vitamin D level and IVF outcome; however, the results are controversial. Sample sizes in these studies mentioned above were relatively small. In addition, there are no prospective cohort studies in this field. Thus, here the investigators carry this prospective observational cohort study to demonstrate the relationship between vitamin D level and IVF outcome.
Vitamin D level is measured before the commence of IVF cycle. According to Vitamin D level, patients are divided into 3 groups: A, Deficient, \<20 ng/mL; B, Insufficient, 20-29.9 ng/mL; C, Replete, \>30 ng/mL. Ongoing pregnancy rate are compared among these three groups after controlling age, number of embryos transferred, ect. In addition, Vitamin D level is also meassured before embryo transfer in FET cycles with PGT treatment. The effect of Vitamin D on IVF outcome is detected in patients transferred with Euploid embryos.
Study Type
OBSERVATIONAL
Enrollment
688
For patients in each group after oocyte retrieval, they will have embryo transferred 3 or 5 days after oocyte retrieval. For FET cycles, they will have ET with an euploid blastocyst.
Reproductive Medical Center, First Affiliated Hospital of Zhengzhou University
Zhengzhou, Henan, China
Ongoing pregnancy rate
12 weeks after embryo transfer, gestational sac with fetal heart present inside uterus
Time frame: 12 weeks after embryo transfer
Ectopic pregnancy rate
Ectopic pregnancy is defined as serum HCG positive, yet with no gestational sac present inside uterine cavity
Time frame: 35 days after embryo transfer
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