The Effects of Morphine on Desflurane Consumption and Recovery Time

Phase 4CompletedNCT02362022

Baskent University90 enrolled

Overview

Combination of volatile and opioid agents are used to achieve unconsciousness, haemodynamic stability and analgesia for surgical prosedures. This prospective, randomized, double-blind, controlled study evaluates the effects of two different doses of morphine sulphate (0.1 mg/kg and 0.2 mg/kg), on desflurane consumption, recovery characteristics, postoperative analgesic requirements and side effects during total abdominal hysterectomy.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

DOUBLE

Enrollment

Conditions

Abdominal Hysterectomy (& Wertheim)

Interventions

MorphineDRUG

Group Saline (Group S): Received i.v saline 0.9 % in 10 ml volume (n=30) Group Morphine 1 (Group M1): Received i.v morphine 0.1 mg kg-1 in 10 ml volume (n=30) Group Morphine 2 (Group M2): Received i.v morphine 0.2 mg kg-1 in 10 ml volume (n=30)

Eligibility

Sex: FEMALEMin age: 40 YearsMax age: 60 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * undergoing total abdominal hysterectomy with general anaesthesia Exclusion Criteria: * renal dysfunction (cre\>1.2), liver failure, cardiovascular, psychiatric, allergic and metabolic disorders

Locations (1)

Baskent University School of Medicine Adana Teaching and Research Hospital

Adana, Turkey (Türkiye)

Outcomes

Primary Outcomes

postoperative desflurane consumption

Time frame: postoperative first hour

sedation scores for OASS scale

Time frame: postoperative first hour

Data from ClinicalTrials.gov

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