A Study to Assess the Safety of HIV and Hep C Vaccine Candidates When Given Separately or in Combination

Inclusion Criteria: * Healthy males or females, as assessed by medical history, physical examination and laboratory tests * Aged at least 18 years on the day of screening and no greater than 50 years on the day of the first vaccination * Resident in or easy access to the trial site for the duration of the study * Available for follow-up for the planned duration of the study * Able and willing (in the Chief Investigator's opinion) to comply with all study requirements * Willing to allow the investigators to discuss the volunteer's medical history with their General Practitioner * For females, willingness to practice continuous effective contraception from screening until 4 months after the last immunisation. * All female volunteers must be willing to undergo urine pregnancy tests at the time points specified in the Schedule of Procedures and must have a negative pregnancy test on the day(s) of vaccination * For sexually active men, willingness to use an approved method of contraception until four months after the last vaccination * Agreement to refrain from blood donation during the course of the study * In the opinion of the Chief Investigator or designee, the volunteer has understood the information provided. Written informed consent must be given before any study-related procedures are performed * Willing to undergo HCV/HIV-1 testing, counselling and receive test results Exclusion Criteria: * Participation in another research study involving an investigational product in the 30 days preceding enrolment, or planned use during the study period * Prior receipt of a recombinant simian adenoviral vaccine * Receipt of any investigational HIV-1 or HCV vaccine within the last 6 years * Administration of immunoglobulins and/or any blood products within the three months preceding the planned administration of the vaccine candidate * Receipt of live attenuated vaccine within the previous 60 days or planned receipt within 60 days after vaccination with the IMP * Receipt of other vaccine, including influenza vaccine, within the previous 14 days or planned receipt within 14 days after vaccination with the IMP * Any confirmed or suspected immunosuppressive or immunodeficient state, including HIV infection; asplenia; recurrent, severe infections and chronic (more than 14 days) immunosuppressive medication within the past 6 months (inhaled and topical steroids are allowed) * History of allergic disease or reactions likely to be exacerbated by any component of the vaccine * History of clinically significant contact dermatitis * Any history of anaphylaxis in reaction to vaccination * Pregnancy, lactation or intention to become pregnant during the study * History of cancer (except basal cell carcinoma of the skin and cervical carcinoma in situ) * History of serious psychiatric condition * Any other serious chronic illness requiring hospital specialist supervision * Suspected or known current alcohol abuse as defined by an alcohol intake of greater than 42 units every week * Suspected or known injecting drug use * Reported high-risk behaviour for HIV-1 / HCV infection * Seropositive for hepatitis B surface antigen (HBsAg) * Seropositive for HIV-1 (antibodies to HIV-1) at screening * Seropositive for hepatitis C virus (antibodies to HCV) at screening * Any other clinically significant acute or chronic medical condition that is considered unstable/progressive, or in the opinion of the Chief Investigator, may either put the volunteer at risk because of participation in the study, or may influence the result of the study, or the volunteer's ability to participate in the study * Any clinically significant abnormal finding on screening biochemistry or haematology blood tests or urinalysis * Any other finding which in the opinion of the investigators would significantly increase the risk of having an adverse outcome from participating in the protocol * Vulnerable subjects (according to ICH GCP)