Exertional symptoms are the hallmarks of metabolic myopathies, supporting the concept of using functional tests when this diagnosis is suspected. Exercise increases the concentration of muscle metabolites in the venous blood supply (e.g. lactate, pyruvate, and ammonia) especially during recovery. The purpose of this study is to compare the results of exercise testing with to the data from muscle biopsy or genetic analysis.
Study Type
OBSERVATIONAL
Enrollment
1,000
subjects perform a metabolic exercise testing
Centre Hospitalier Régional Universitaire
Brest, France
RECRUITINGWhole-body dynamic exercise
The relation between Cardiopulmonary exercise test variables and the results of muscle biopsy or genetic analysis will be evaluated.
Time frame: Participants will be followed for an expected average of 1 year to determine whether a muscle biopsy is performed
Grip-test
The relation between Grip-test variables and the results of muscle biopsy or genetic analysis will be evaluated.
Time frame: Participants will be followed for an expected average of 1 year to determine whether a muscle biopsy is performed
Blood tests
The results of blood analysis from samples performed before, during, and after exercise will be compared to the results of muscle biopsy or genetic analysis.
Time frame: Participants will be followed for an expected average of 1 year to determine whether a muscle biopsy is performed
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