Analysis of CA-MRSA Transmission: An ED Population Sampling Strategy

University of Florida575 enrolled

Overview

Given that the Emergency Department (ED) has become the entry way for large populations of patients into the health care system, a strategy of sampling MRSA isolates in ED populations and merging this information with patient-level data may present a window to hypothesize and investigate CA-MRSA transmission within the community and its impact on hospital-acquired infections.

Prospective cross-sectional study involving 500 patients enrolled over a one year period at the UFHealth Shands Hospital's Adult and Pediatric Emergency Department. The collected information will serve as pilot data for a future large comprehensive multi-site study. Patients will have a wound culture and a nasal swab obtained as part of the study, which will be assessed for MRSA isolates using next-generation whole genome sequencing. The principal investigator or PI designee will also survey participants and review hospital records.

Study Type

OBSERVATIONAL

Enrollment

575

Conditions

Methicillin-Resistant Staphylococcus Aureus

Interventions

Acute Abscess GroupOTHER

Samples collected for culture and sensitivity testing depending on acute abscess, or skin/soft tissue infection.

Eligibility

Sex: ALLMin age: 1 Month

Medical Language ↔ Plain English

Inclusion Criteria: * Patient or Legally Authorized Representative (LAR) must have voluntarily signed an Institutional Review Board-approved informed consent form before initiation of any study procedures * Patient presents with an acute abscess or a non-post-operative skin/soft tissue infection * Patient presents through the UFHealth Shands Emergency Department Exclusion Criteria: * Patients who are employed by UFHealth and provide direct patient care * Patients who have previously been enrolled in the study * Patients who are not suitable for the study in the opinion of the investigator

Locations (1)

UF Health

Gainesville, Florida, United States

Outcomes

Primary Outcomes

Strain Relatedness Identification Through Phylogenetic Analysis

Molecular (spa-typing) and genomic (WGS) relatedness of MRSA strains in isolates in ED populations presenting with SSTIs.

Time frame: 1 Hour

Secondary Outcomes

Strain Transmission Through Analysis of Genetic Clustering

Phlyodynamic analysis of MRSA transmission course by strain

Time frame: 1 year

Patient Level Characteristics of Skin and Soft Tissue Infection (SSTI) Presentation

To determine patient-level characteristics, including social and medical history, associated with a presentation related to SSTIs.

Time frame: 6 Months

Pediatric and Adult Population Presentation Characteristics in Skin and Soft Tissue Infection (SSTI)

Compare patient-level characteristics and phylogenetic clustering between pediatric and adult patients presenting with SSTIs.

Time frame: 6 Months

Data from ClinicalTrials.gov

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