The TAP Study: Treating People Who Inject Drugs in Community-Based Settings Using a Social Network Approach

SECONDARY PARTICIPANTS INCLUSION AND EXCLUSION CRITERIA Study INCLUSION criteria for primary participants are as follows: * Current PWID (i.e., injected any drug at least once during the previous six months); * Evidence of chronic HCV infection (detectable plasma HCV RNA viral load above 1000 IU/ml on two occasions ≥ 6 months apart) * Willing and able to provide written informed consent. Subjects must have the following laboratory parameters at screening: * ALT \<10 times the upper limit of normal (ULN) * AST \<10 times ULN * Haemoglobin ≥12g/dL for males, ≥11g/dL for female subjects * INR ≤1.5 times ULN unless is stable on an anticoagulant regimen affecting INR * Albumin ≥3g/dL * Direct bilirubin ≤1.5 times ULN * Creatinine clearance (CLcr) ≥60mL/min, as calculated by the Cockcroft-Gault Equation. EXCLUSION criteria for all primary participants are as follows: * Testing positive for HIV * History of, or current, decompensated liver disease * Testing positive for HBsAg * HCC * Women who are pregnant or breastfeeding, or men with female partners who are pregnant at screening or baseline, or who were pregnant in the six months prior to screening * Already enrolled in the TAP Study as a secondary participant (see below) * Evidence of any condition, therapy, laboratory abnormality or other circumstance (current or prior) that may confound the study's results, or interfere with participation for the full duration of the study, such that it is not in the best interest of the participant; * Use of concomitant medications. Additional EXCLUSION criteria for primary participants with HCV genotypes 2-6: * Increased baseline risk for anaemia (e.g., a history of thalassemia, spherocytosis, history of GI bleeding), or for whom anaemia would be medically problematic; * Documented or presumed coronary artery disease or cerebrovascular disease if, in the judgment of the investigator, an acute decrease in haemoglobin by up to 4g/dL (as may be seen with ribavirin therapy) would not be well-tolerated. SECONDARY PARTICIPANTS INCLUSION AND EXCLUSION CRITERIA The INCLUSION criteria for secondary participants are as follows: * Is nominated by a primary participant as a current injecting partner (i.e., has engaged in IDU with a primary participant in the previous six months) * Willing and able to provide written informed consent. There are no exclusion criteria for secondary participants who are not receiving HCV therapy in this protocol: EXCLUSION criteria for treated secondary participants (i.e., those in Group C who are HCV positive) are as follows: * History of, or current, decompensated liver disease * Women who are pregnant or breastfeeding, or men with female partners who are pregnant at screening or baseline, or who were pregnant in the six months prior to screening * Testing positive for HIV * Testing positive for HBsAg * HCC * Evidence of any condition, therapy, laboratory abnormality or other circumstance (current or prior) that may confound the study's results, or interfere with participation for the full duration of the study, such that it is not in the best interest of the participant * Use of concomitant medications. Additional EXCLUSION criteria for secondary participants with HCV genotypes 2-6: * Increased baseline risk for anaemia (e.g. a history of thalassemia, spherocytosis, history of GI bleeding) or for whom anaemia would be medically problematic * Documented or presumed coronary artery disease or cerebrovascular disease if, in the judgment of the investigator, an acute decrease in haemoglobin by up to 4g/dL (as may be seen with ribavirin therapy) would not be well-tolerated.