The purpose of this study is to examine the effect of mitochondria derived oxidative stress on vascular function in patients with moderate to severe Chronic Kidney Disease.
Chronic Kidney Disease (CKD) patients are at increased risk of cardiovascular disease. Endothelial dysfunction, characterized by a reduced bioavailability in nitric oxide, is an independent predictor of cardiovascular disease in CKD. Increased oxidative stress is a potential cause of endothelial dysfunction in this patient cohort. This study investigates the role that mitochondrial derived oxidative stress plays in CKD related vascular dysfunction. In a controlled, double blinded trial, Stage 3-5 CKD patients will be randomly assigned to receive a 4 week daily dose of a mitochondria targeted antioxidant (MitoQ) or a placebo.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
TRIPLE
Enrollment
24
Department of Kinesiology and Applied Physiology, University of Delaware
Newark, Delaware, United States
RECRUITINGMicrovascular Function, assessed by laser Doppler flowmetry coupled with microdialysis
Nitric oxide mediated cutaneous microvascular dilatory response to local heating assessed by laser Doppler flowmetry coupled with microdialysis
Time frame: Change from baseline at 4 weeks
Conduit artery endothelial dependent dilation, assessed by duplex ultrasound
Brachial artery flow mediated dilation assessed by duplex ultrasound
Time frame: Change from baseline at 4 weeks
Mitochondria derived superoxide, assessed by electron paramagnetic resonance spectroscopy
Plasma mitochondria superoxide assessed by electron paramagnetic resonance spectroscopy
Time frame: Change from baseline at 4 weeks
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