A Study Evaluating Biomarkers in Participants With Heart Failure (MK-0000-344)

Inclusion Criteria: * female of reproductive potential must demonstrate non-pregnant state, and agree to use two acceptable methods of birth control * postmenopausal or surgically sterile female * have a Body Mass Index (BMI) \>= 18 and =\< 35 kg/m\^2, inclusive * healthy participants are in general good health * participants with HF have no untreated, significant health issue from other co-morbidities, e.g. uncontrolled hypertension * is willing to undergo echocardiography, CMR, and other study assessments * participants with HF have a diagnosis of cardiomyopathy, and slight to moderate limitation of physical activity, but are comfortable at rest * participants with HF are on a stable medical therapy for HF for two weeks prior to start of Part 1 * participants with HF are on a stable diuretic regimen of \>= 40 mg/day furosemide or \>= 10 mg/day torsemide for at least 2 weeks prior to start of Part 1 Exclusion Criteria: * has any clinically significant, uncontrolled renal, endocrine (except Type II Diabetes), neurological, hepatic, immunological or inflammatory disease * has a history of cancer (malignancy) * had major surgery or donated/lost approximately 500 mL of blood within 4 weeks prior to screening * participated in another investigational trial within 4 weeks prior to screening * excepting permitted medications, uses prescription, or non-prescription drugs or herbal remedies 2 weeks prior to enrollment until completion of trial * takes medications that affect BNP levels within 30 days prior to screening * undergoes high-intensity physical exercise from 1 week prior to pretrial visit until completion of trial * has implanted or embedded metal objects in body that in response to a magnetic field could cause injury * suffers from claustrophobia making them unable to undergo CMR scanning * consumes alcohol for 7 days prior to screening until completion of study * consumes excessive amounts of caffeinated beverages * uses cannabis regularly, or any illicit drugs, or has a history of drug (including alcohol) abuse within prior 12 months